About 60% of the United States population possesses a refractive correction aid. Although the majority of this population relies on spectacles or contact lenses, the permanent correction of refractive error is an attractive choice for many patients. It is estimated that almost 1 million patients undergo corneal refractive surgery each year in the United States alone.
While osteoarthritis is understood today to be a disease of the joint as an organ, with bone, cartilage, and synovial fluid involved, it is believed that the pathological progression occurs due to the initial disturbance of the extracellular matrix homeostasis in articular cartilage. The work of this project aims to develop tools to characterize these transformations at the earliest stages and couple it with a treatment that would be less invasive than what is currently available.